Everything about The Retinoic Acid Receptor totally explained
The
retinoic acid receptor (RAR) is a type of
nuclear receptor which is activated by both
all-trans retinoic acid and
9-cis retinoic acid. There are three retinoic acid receptors (RAR),
RAR-alpha,
RAR-beta, and
RAR-gamma encoded by the,, genes respectively. Each receptor isoform has several splice variants: two- for alpha, four- for beta and two- for gamma.
As with other
type II nuclear receptors, RAR heterodimerizes with
RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements complexed with
corepressor protein. Binding of agonist
ligands to RAR results in dissociation of corepressor and recruitment of
coactivator protein which in turn promotes
transcription of the downstream target
gene into
mRNA and eventually
protein.
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